Your Liver Makes Sugar Gluconeogenesis is the metabolic process of making new sugar in the body from non-carbohydrate substances such as amino acids. This process primarily occurs in the liver and is triggered by stress hormones from the adrenal glands during times of stress, sudden drops in energy (hypoglycemia), and from taking stimulants (such as caffeine). Gluco - means sugar neo - means new genesis - means creation #medicine