How does clone evolution work? There are two mechanisms at work here. The first is during the cloning process itself where unless you write the clone's genome instead of copying from a cell you will get mutations as a natural product of DNA replication. The second is when a source cell has preexisting mutations from cell division and life. It's not easy to make a perfect genetic copy of any organism and if you want more genetic variation you can inject mutations via CRISPER9 overseen by a system that won't add any known diease mutations.