Physicians for Informed Consent (PIC), an educational nonprofit organization focused on science and statistics, recently responded in the BMJ to Professor Peter Gøtzsche’s statement on May 24, 2019, “Rational doubt cannot be raised about the measles vaccine.” Gøtzsche’s response was to PIC’s assertion that “it has not been proven that the MMR vaccine results in less death or permanent disability than what is expected from measles.” To read the full comments, please visit bmj.com/content/359/bmj.j5104/rapid-responses. Gøtzsche went on to write that “the reason that so few people die or get seriously injured from measles is that most of the population is vaccinated.” However, it is a documented fact that before the vaccine was introduced in the United States, measles was only fatal in 1 in 10,000 cases. Consequently, to prove the vaccine causes less permanent injury than measles, vaccine safety studies must have the statistical power to detect permanent injury in as little as 1 in 10,000 vaccinated children. Dr. Shira Miller, PIC’s founder and president, states, “Rational doubt will continue to be raised about the measles-containing vaccine MMR until a safety study with the statistical power to detect permanent injury from the vaccine in 1 in 10,000 vaccinated subjects is produced.”