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Ascorbic Acid mega Compile 2019

uniqueleeFeb 19, 2019, 12:38:13 PM


Chronology of peer reviewed paper studied (120+ scientific papers)

1. 1893 The Discovery of Vitamin C - Albert Szent Gyogyi

1935 Vitamin C and Polio - Jungblut


1941 Fred Klenner - Haemorrhagic Fevers – The Use of Vitamin C as an Antibiotic

1948 William J McCormick M.D - Vitamin C Hyperscorbemia and Cancer One and the Same

1949 Fred Klenner - The Treatment of Poliomyelitis and Other Virus Diseases with Vitamin C

1951 Fred Klenner - Massive Doses of Vitamin C and the Virus Diseases

1951 The effect of ACTH, cortisone, and DCA with ascorbic acid on formalin-arthritis

10. 1951 Vaccination Proved Useless and Dangerous - 45 years of registration statistics

1952 Cortisone and Ascorbic Acid in Chorea (Tardive Dyskinesia and shakes)

1952 Cortisone-ascorbic acid interaction and the pathogenesis of amyloidosis

1952 Cortisone-ascorbic acid interaction and the pathogenesis of amyloidosis - Mechanism of Action of cortisone mesenchymal tissue

1953 The effect of cortisone and adrenocorticotropic hormone on the dehydroascorbic acid of human plasma

1954 Metabolism of dehydroascorbic acid and the effect of adrenocorticotrophic hormone and cortisone

1957 Fred Klenner and Vitamin C - The Black Widow Spider

1963 British Journal of Psychciatry - Ascorbic Acid in Chronic Psychiatric Patients - A Controlled Trial


1970 Effect of Dietary Ascorbic Acid on Performance and Plasma cholesterol levels

20. 1971 Fred Klenner - Vitamin C paper

1974 Fred Klenner - Significance of High Daily doses of Ascorbic acid preventative medicine


1975 Effect of ascorbic acid on histamine metabolism in scorbutic guinea-pigs (Chattergee)

1976 Inability of bats to synthesise L-ascorbic acid

1978 How Vitamin C Really Works or does it

1979 Ascorbic Acid and Cancer - A Review

1979 p53 Guardian of the Genome studies

1979 Sodium Ascorbate potentiates the growth inhibitory effect of certain agents neuroblastoma cells

1986 Ascorbate induced changes in glycosaminoglycan synthesis and distribution of normal and SV40-transformed fibroblasts

30. 1987 Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by Ascorbic Acid

1988 The Role of Vitamine C in Immune System

1988 Regulation of collagen metabolism and cell growth by epidermal growth factor and ascorbate in cultured human skin fibroblasts

1990 Case Study - High-Dose Intravenous Vitamin C in the Treatment of a Patient with Adenocarcinoma of the Kidney

1991 Robert Landwehr - The Origin of the 42 year old stonewall of Vitamin C

1993 Pilot study of ascorbic acid for the treatment of refractory immune

1995 Levels of pyrroloquinoline quinone (PQQ) in various foods

1995 p53 expression in nitric oxide-induced apoptosis (See Cancer and ASTHMA/COPD Studies)

1997 Functional Requirement of the Hypoxia-responsive Element in the activation of inducible NO synthase

1999 Effects on normal firbroblasts and neuroblastoma cells of the activation of p53

40. 1999 Stromal Cell Oxidation A Mechanism by Which Tumors obtain Vitamine C

2001 Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours

2002 Wilson et al - The physiological role of dehydroascorbic acid

2002 Intracellular ascorbate depletion increases nitric oxide synthase induction and glutamate uptake Inhibition

2003 November 26: A-Bomb Scientist Theodore p Jorgensen Manhattan Project Recommends Vitamin C and lots of it

2003 Vitamin C Transforms Mouse Stem Cells Into Heart Muscle Cells

2004 Enhancement of Nitric Oxide and Superoxide alpha tocopherol and anti cancer gut Neuons

*2005 Molecular and Cellular Regulation of GlucoseTransporter (GLUT) Proteins in Cancer

2005 PNAS Pharmacologic ascorbic acid concentrations selectively kill cancer cell

2005 Reaction of Artemisinin with haemoglobin and Vitamin B1 Th1 CD4+ CD8+ T helper cells

50. 2005 Using Vitamin C to Neutralize Chlorine in Water Systems

2006 Intravenously administered vitamin C as cancer therapy - 3 Cases

2006 A pilot clinical study of continuous intravenous ascorbic acid in terminal cancer patients

2006 Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375 and increases p53

2006 Vitamin C: A new role of the old vitamin in the cardiovascular system

**2007 Book - Virus Mania**

2007 Vitamin C and Vitamin status of the host and its effect on Plasmodium Inactivation development

*2007 Sodium Ascorbate induces apoptosis in Human neuroblastoma cell lines by interfering with Iron uptake

2007 Malaria Vitamin C and B1 and B3 B5 B6 co-factor biosynthesis pathways in Plasmodium Fulcicarum and other apicomplexan parasites

*2008 GLUT1 triggers dehydroascorbic acid in mammals unable to make Vitamine C

60. 2009 High dose Vitamin C (Ascorbic Acid) Therapy in the treatment of Cancer

2009 Mechanism of action of vitamin C in sepsis Ascorbate modulates Redox Signalling in Endothelium

2009 Oxalic acid excretion after intravenous ascorbic acid

2009 Seoul - The Prospects of Vitamin C in Cancer Therapy

2010 National Institute of Health mechanism of Ascorbate-induced Cytotoxicity

2010 Vitamin C Intravenous Use of Complementary and Alternative Medicine (CAM)

2011 Cellular Nutrition Orthomolecular Medicine Dec Jan Dogs Diet

2011 Scurvy in a patient with AIDS

2011 The Genetics of Vitamin C Loss in Vertebrates

2011 Vitamin C A Concentration Function Approach Yields Pharmacology

70. *2011 Intravenous Vitamin C Administration Improves Quality of Life in Breast Cancer Patients during Chemo Radiotherapy

2011 Vitamin C Deficiency - More than a nutritional disorder

*2011 Vitamin K3 and vitamin C alone or in combination destroys leukemic cells

2012 Ascorbic Acid Chemistry, biology and the treatment of cancer

2012 Effect of high-dose intravenous vitamin C in Cancer Patients

2012 Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy

*2012 Effect of high-dose intravenous vitamin C on inflammation in cancer patients

2012 Phase I Evaluation of IV AA in combo with Gemcitabine and Erlotinib Mestastic Pancreatic Cancer

2012 Vitamin C transport and its role in the central nervous system

2012 Molecular and cellular mechanisms of cigarette smoke-induced myocardial injury Prevention by Vitamin C

80. 2013 Anti-proliferative Effect of Ascorbic Acid Is Associated with the inhibition of Genes p52 Tumour Suppressor gene

2013 Chlorine Dioxide as a Selective antimicrobial Agent

2013 European Food Safety Authority (EFSA), Parma, Italy Vitamine C in Animal Feed Safety

2013 Glutamate - a metabolic biomarker of aggressiveness and a potential therapeutic target for prostate cancer

2013 Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C transport and Antioxidant Enzyme Function

2013 Myths Artifacts and Flaws - Identifying Limitations and Opportunities in Vitamin C Research

2013 Parenteral Ascorbate as a Cancer Therapeutic - A Reassessment Based on Pharmacokinetics

2013 Pharmacological activities of turmeric curcuma longa linn- a review

2013 Redux Signalling Parenteral Ascorbate as a Cancer Therapeutic

2013 Riordan IVC Protocol

90. 2013 Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbate acid in cancer patients

2013 Synthetic or Food-Derived Vitamin C - Are They Equally Bioavailable

2013 Role of Vitamin C in the Function of Vascular endothelium

2013 Vitamin C helps eliminate Chronic Disease

2013 The Effect of Ascorbic Acid and Garlic Administration on Lead Induced Apoptosis

2013 Vitamin C further improves the protective effect of glucagon-like peptide-1

2014 Serbian Journal of Experimental and Clinical Research Vitamin C In Neuropsychiatry

2014 Co-expression of CD147 and GLUT-1 indicates radiation resistance

2014 Intravenous ascorbic acid as an adjuvant to Interleukin-2 immunotherapy

2014 Intravenous Vitamin C A cancer killer the FDA wants banned

100. 2014 Anger as charity promotes 3000 pound Intravenous Vitamin C (News article)

*2014 Regulation of NF-κB by TNF Family Cytokines

2014 Ebola virus can be destroyed by Vitamin C


2014 Vitamin C is the muscle of the immune System

2014 Wilsom Review of high-dose intravenous vitamin C Asian anticancer agent

2014 Molecular Expression and Functional Activity of Vitamin C Specific Transport System (SVCT2) in Human Breast Cancer Cells

2014 There's life in the old dog yet Vitamin C as a Therapeutic option in endothelial dysfunction

2015 Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in treating Patients with Cancer?

*2015 Intracellular Ascorbate Prevents Endothelial Barrier Permeabilization by Thrombin

110. 2015 Low Red Blood Cell Vitamin C Concentrations Induce Red Blood Cell Fragility Diabetes Via Glucose Transporters Dehydroascorbic Acid

*2015 Interactions between Hyaluronan and its receptors CD44 regulate the activities of inflammation and cancer

2015 Mechanisms and Applications of Ιnterleukins in Cancer Immunotherapy

2015 Treatment of Irradiated Mice with High-Dose Ascorbic Acid Reduced Lethality

2016 Determination of plasma and leukocyte vitamin C concentrations with Ester-C

2016 Effect of Intravenous High Dose Vitamin C on Postoperative Pain

*2016 The sweet trap in tumors aerobic glycolysis and potential targets for therapy CD147 CD44

2016 Linus Pauling

2016 The Epigenetic Role of Vitamin C in Health and Disease

2016 A Review Based on Findings from Epidemiologic Studies Vitamin C and Healthy Heart

120. *2017 Ancient oncogenesis infection and human evolution

2017 The role of vitamin C in the treatment New Insights

2017 Ascorbic Acid for Immune Function

2017 Comparative assessment of methylcobalamin and ascorbic acid on cognitive function in post-menopausal women - A randomized, double-blind trial

2017 Vitamin C and Immune Function

2018 Role of CD44 in Regulating Toll-like Receptor 2 TLR2 Activation of Human Macrophages pro-inflammatory Cytokines

2018 Journal of Pain Research Enhanced expression of gene coding for β-endorphin in human monocytic cells

2018 Vitamin C and immune cell function in inflammation and cancer

128. 2019 A screen of Crohn’s disease-associated microbial metabolites identifies Ascorbate as a novel metabolic inhibitor of activated human T Cells

Additional 20 paepers on : Ascorbic Acid and Sepsis and Septic Shock

1. 1983 Changes in Synthesis distribution and sulphation of Glycosaminoglycans skin fibroblasts ascorbate feeding

2. 2006 Ascorbic acid deficiency stimulates hepatic expression of inflammatory chemokine, cytokine-induced neutrophil chemoattractant-1, in scurvy-prone ODS rats

3. 2009 Mechanism of action of vitamin C in sepsis ascorbate modulates redox signalling in endothelium

4. 2011 Intravenous ascorbic acid to prevent and treat cancer-associated sepsis

5. 2011 Vitamins C and E - beneficial effects from a mechanistic perspective

6. 2013 Clinical experience with intravenous administration of ascorbic acid - achievable levels in blood for different states of inflammation and disease in cancer patients

7. 2013 Evaluation of vitamin C for adjuvant sepsis therapy

8. 2013 Iron-ascorbate-mediated lipid peroxidation causes epigenetic changes in the antioxidant defense in intestinal epithelial cells

9. 2014 Cognitive deficits and decreased locomotor activity induced by single-walled carbon nanotubes and neuroprotective effects of ascorbic acid

10. 2014 Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

11. 2014 Vitamin C treatment attenuates hemorrhagic shock related multi-organ injuries through the induction of heme oxygenase-1

12. 2015 Ascorbate-dependent vasopressor synthesis - a rationale for vitamin C administration in severe sepsis and septic shock

13. 2015 Biomarkers of Oxidative Stress Study VI. Endogenous Plasma Antioxidants Fail as Useful Biomarkers of Endotoxin-Induced Oxidative Stress

14. 2015 Effect of vitamin C on inflammation and metabolic markers in hypertensive diabetic obese adults

15. *2016 Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

16. 2017 Hypovitaminosis C and vitamin C deficiency

17. 2018 Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid

18. 2018 Intravenous vitamin C in the supportive care of cancer patients - a Review and rational approach

19. 2018 Vitamin C in sepsis

20. 2009 Mechanism of action of vitamin C in sepsis ascorbate modulates redox signalling in endothelium


1981 Robert F Cathcart - How to prepare Sodium Ascorbate for IV and Vitamin C Titrating to tolerance

1948 Fred Klenner - Clinical Guide to the Use of Vitamin C

Irwin Stone - 50 years of research on Ascorbate and Scurvy, On the Genetic Etiology of Scurvy, The Genetics of Scurvy and the Cancer Problem, The Natural History of Ascorbic acid in the evolution of mammals