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Artemesinin Annua - A natural remedy for a Parasitic Infection

uniqueleeApr 7, 2020, 7:48:39 AM

This is my culmination of studies into a viable remedy for the "COV1D-19" parasite (with sources included)

Artemesinin Annua Profile Page 1

Artemesinin Annua Profile Page 2

Artemesinin Annua Profile Page 3

1 2012, Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies - Reaction of Artemisinins with iron (nonheme or heme iron) received much attention for at least the following two reasons: Artemesinin contains a peroxy group, which is reminiscent of the Fenton reaction, wherein H2O2 is catalysed by ferrous iron or cupric copper to produce the HO free radical. It was proposed that free radicals generated from iron and Artemisinin reaction mediate the antimalarial action of Artemesinin.

2 2010, the Molecular Mechanism of Action of Artemisinin - The Debate Continues

3 2015, an extract of the medicinal plant Artemisia annua modulates production of inflammatory markers in activated neutrophils - To investigate the ability of a commercial extract from the medicinal plant Artemisia annua to modulate production of the cytokine, tumor necrosis factor-alpha (TNF-α), and the cyclooxygenase (COX) inflammatory marker, prostaglandin E2 (PGE2) in activated neutrophils (activated with 10 μg/mL lipopolysaccharide (LPS).

4 2015, Anti-inflammatory, Antioxidant and Antimicrobial Effects of [Korean medicinal plant ] Artemisinin Extracts from Artemisia annua L. - Gram-negative anaerobic bacteria are the etiologic agents of periodontal disease

5 2016, A Systematic Review of Anti-malarial Properties, Immunosuppressive Properties, Anti-inflammatory Properties, and Anti-cancer Properties of Artemisia Annua - the initial search strategy identified around 128 references. In this study, 46 studies were accepted for further screening and met all of our inclusion criteria, March 1990 to March 2016

6 2016, Overexpression of AaWRKY1 Leads to an Enhanced Content of Artemisinin in Artemisia annua

7 2019, The modulatory effect of Artemisia annua L. on toll-like receptor expression in Acanthamoeba infected mouse lungs.

8 2015, Influence of Artemisia annua extract derivatives on proliferation, apoptosis and metastasis of osteosarcoma cells.

9 2017, Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through ERK1 -2 signalling pathway

10 2019 Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

11 2020, Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream

12 2013, Evaluation of the In Vitro Efficacy of Artemisia annua, Rumex abyssinicus, and Catha edulis Forsk Extracts in Cancer and Trypanosoma brucei Cells (MCF-7, THP-1, PC-3, LNCaP, Du-145 and Astrocytoma 1321N1 cancer cells), Among all cell lines tested, LNCa P prostate cancer andTHP-1 leukemia cells were found to be most susceptible to the inhibitory effects of all the three plant extracts, where their IC50s lay below 33𝜇g/mL.

13 2014, Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin - Monoterpenes isolated from eucalyptus oil (80% 1,8-cineole) inhibit chloroquine resistant and chloroquine-sensitive P. falciparum by mechanisms thought related to membrane disruption -

14 2014, Essential Oil of Artemisia annua L.: An Extraordinary Component with Numerous Antimicrobial Properties

 15 2016, Anti‑allergic effect of Artemisia extract in rats

16 2016, Anti‑inflammatory and acetylcholinesterase activity of extract, fractions and five compounds isolated from the leaves and twigs of Artemisia annua growing in Cameroon

17 2014, Antimicrobial Activity of Artemisinin and Precursor Derived from In Vitro Plantlets of Artemisia annua L.

18 2016, Artemisia annua Leaf Extract Attenuates Hepatic Steatosis and Inflammation in High-Fat Diet-Fed Mice

19 2017, Apoptosis-induced effects of extract from Artemisia annua Linné by modulating PTEN/p53/PDK1/Akt/ signal pathways through PTEN/p53-independent manner in HCT116 colon cancer cells

20 2017, Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signalling pathway in diet-induced obesity mouse model

21 2016, Artemisinin, a Potential Antimalarial Drug: Current Status

22 2017, Artemisia annua extract prevents ovariectomy-induced bone loss by blocking receptor activator of nuclear factor kappa-B ligand-induced differentiation of

Osteoclasts (Female menopause and bone loss)

23 2007, Osteoporosis and Inflammation - Since this early study, a long list of pro-inflammatory cytokines has been shown capable of stimulating osteoclastic bone resorption including interleukin IL-1,[11–16] tumor necrosis factor alpha (TNF-a),[15–19] IL-6,[20 –22] IL-11,[23,24] IL-15,[25] and IL-17.[26]

24 2019, Methanolic Extract from Aerial Parts of Artemisia Annua L. Induces Cytotoxicity and Enhances Vincristine-Induced Anticancer Effect in Pre-B Acute Lymphoblastic Leukemia Cells

25 2017, Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle – (Mice obtained from Hubei Provincial Center for Disease Control and Prevention, Wuhan, China

26 2019, Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)